Chemical Reactivity resources and references

In January, 2022, an inquiry to the DCHAS-L asked for suggestions for resources to evaluate reactivity hazards associated with teaching lab organic syntheses  organic synthesis or compounds involved in drug manufacturing. Below is a list of the references that were suggested in response to this request. If you know of other resources that should be included or entries that should be updated, let us know in the comments below.

Note: some of these references are free; others are require a fee to view. Many academic libraries can provide access to specific entries for these resources.


CHAS workshop on the chemical reactivity hazards

Univ of Rhode Island Explosives Courses

Computer Application

AIChE CCPS Chemical Reactivity Worksheet (2019)

CAMEO chemicals:

Ongoing Literature

CAS Chemical Safety Library:

C&EN Safety Letters:

Organic Syntheses:

OPRD ACS journal: 

Science of Synthesis at Stanford Library guide to chemical safety resources:

Chemical Safety Board web site on reactive chemicals:

Chemical Safety Board web site on laboratory safety

Other Literature Sources

Thermal Safety of Chemical Processes: Risk Assessment and Process Design, Second, Completely Revised and Extended Edition
Francis Stoessel (2020)

Process Safety in the Pharmaceutical Industry—Part I: Thermal and Reaction Hazard Evaluation Processes and Techniques (2020)

Bretherick’s Handbook of Reactive Chemical Hazards (2017)

Wiley’s Guide to Chemical Incompatibilities (2009)

March’s Organic Synthesis (2006)

Encyclopedia of Reagents for Organic Synthesis (2001)

Fieser and Fieser’s Reagents for Organic Synthesis (1989)

7 thoughts on “Chemical Reactivity resources and references”

  1. Thank you Ralph for collating and organizing all of these references. This is critical information to chemists. Great job!

  2. Hi Ralph, Thank you very much for providing all these references. These links will be very helpful to chemistry students for risk assessment purposes. Excellent.

    1. Thanks for noticing this. I have replaced the OPRD article reference, as well as the CSB link you suggested.

      – Ralph

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