Chemical Reactivity resources and references

In January, 2022, an inquiry to the DCHAS-L asked for suggestions for resources to evaluate reactivity hazards associated with teaching lab organic syntheses  organic synthesis or compounds involved in drug manufacturing. Below is a list of the references that were suggested in response to this request. If you know of other resources that should be included or entries that should be updated, let us know in the comments below.

Note: some of these references are free; others are require a fee to view. Many academic libraries can provide access to specific entries for these resources.

Workshops

CHAS workshop on the chemical reactivity hazards http://www.dchas.org/workshops

Univ of Rhode Island Explosives Courses
http://energetics.chm.uri.edu/?q=node/95

Computer Application

AIChE CCPS Chemical Reactivity Worksheet (2019)
https://www.aiche.org/ccps/resources/chemical-reactivity-worksheet

CAMEO chemicals:
https://cameochemicals.noaa.gov

Ongoing Literature

CAS Chemical Safety Library: https://safescience.cas.org

C&EN Safety Letters: http://pubsapp.acs.org/cen/safety/

Organic Syntheses: http://www.orgsyn.org

OPRD ACS journal: https://pubs.acs.org/toc/oprdfk/0/0 

Science of Synthesis at Stanford Library guide to chemical safety resources: https://guides.library.stanford.edu/lab-safety/recognize-hazards/reactive-substances

Chemical Safety Board web site on reactive chemicals: https://www.csb.gov/reactive-hazards/

Chemical Safety Board web site on laboratory safety
https://www.csb.gov/laboratory-safety/

Other Literature Sources

Thermal Safety of Chemical Processes: Risk Assessment and Process Design, Second, Completely Revised and Extended Edition
Francis Stoessel (2020)


Process Safety in the Pharmaceutical Industry—Part I: Thermal and Reaction Hazard Evaluation Processes and Techniques (2020)
https://pubs.acs.org/doi/10.1021/acs.oprd.0c00226

Bretherick’s Handbook of Reactive Chemical Hazards (2017)
https://www.elsevier.com/books/brethericks-handbook-of-reactive-chemical-hazards/urben/978-0-08-100971-0

Wiley’s Guide to Chemical Incompatibilities (2009)
https://www.wiley.com/en-us/Wiley+Guide+to+Chemical+Incompatibilities%2C+2nd+Edition-p-9780471721628

March’s Organic Synthesis (2006)
https://onlinelibrary.wiley.com/doi/book/10.1002/0470084960

Encyclopedia of Reagents for Organic Synthesis (2001) https://www.wiley.com/en-us/Fieser+and+Fieser%27s+Reagents+for+Organic+Synthesis%2C+Volume+14-p-9780471504009

Fieser and Fieser’s Reagents for Organic Synthesis (1989)
https://www.wiley.com/en-us/Fieser+and+Fieser%27s+Reagents+for+Organic+Synthesis%2C+Volume+14-p-9780471504009

7 thoughts on “Chemical Reactivity resources and references”

  1. Thank you Ralph for collating and organizing all of these references. This is critical information to chemists. Great job!

  2. Hi Ralph, Thank you very much for providing all these references. These links will be very helpful to chemistry students for risk assessment purposes. Excellent.

    1. Thanks for noticing this. I have replaced the OPRD article reference, as well as the CSB link you suggested.

      – Ralph

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