In January, 2022, an inquiry to the DCHAS-L asked for suggestions for resources to evaluate reactivity hazards associated with teaching lab organic syntheses organic synthesis or compounds involved in drug manufacturing. Below is a list of the references that were suggested in response to this request. If you know of other resources that should be included or entries that should be updated, let us know in the comments below.
Note: some of these references are free; others are require a fee to view. Many academic libraries can provide access to specific entries for these resources.
Workshops
CHAS workshop on the chemical reactivity hazards http://www.dchas.org/workshops
Univ of Rhode Island Explosives Courses
http://energetics.chm.uri.edu/?q=node/95
Computer Application
AIChE CCPS Chemical Reactivity Worksheet (2019)
https://www.aiche.org/ccps/resources/chemical-reactivity-worksheet
CAMEO chemicals:
https://cameochemicals.noaa.gov
Ongoing Literature
CAS Chemical Safety Library: https://safescience.cas.org
C&EN Safety Letters: http://pubsapp.acs.org/cen/safety/
Organic Syntheses: http://www.orgsyn.org
OPRD ACS journal: https://pubs.acs.org/toc/oprdfk/0/0
Science of Synthesis at Stanford Library guide to chemical safety resources: https://guides.library.stanford.edu/lab-safety/recognize-hazards/reactive-substances
Chemical Safety Board web site on reactive chemicals: https://www.csb.gov/reactive-hazards/
Chemical Safety Board web site on laboratory safety
https://www.csb.gov/laboratory-safety/
Other Literature Sources
Thermal Safety of Chemical Processes: Risk Assessment and Process Design, Second, Completely Revised and Extended Edition
Francis Stoessel (2020)
Process Safety in the Pharmaceutical Industry—Part I: Thermal and Reaction Hazard Evaluation Processes and Techniques (2020)
https://pubs.acs.org/doi/10.1021/acs.oprd.0c00226
Bretherick’s Handbook of Reactive Chemical Hazards (2017)
https://www.elsevier.com/books/brethericks-handbook-of-reactive-chemical-hazards/urben/978-0-08-100971-0
Wiley’s Guide to Chemical Incompatibilities (2009)
https://www.wiley.com/en-us/Wiley+Guide+to+Chemical+Incompatibilities%2C+2nd+Edition-p-9780471721628
March’s Organic Synthesis (2006)
https://onlinelibrary.wiley.com/doi/book/10.1002/0470084960
Encyclopedia of Reagents for Organic Synthesis (2001) https://www.wiley.com/en-us/Fieser+and+Fieser%27s+Reagents+for+Organic+Synthesis%2C+Volume+14-p-9780471504009
Fieser and Fieser’s Reagents for Organic Synthesis (1989)
https://www.wiley.com/en-us/Fieser+and+Fieser%27s+Reagents+for+Organic+Synthesis%2C+Volume+14-p-9780471504009
Thank you Ralph for collating and organizing all of these references. This is critical information to chemists. Great job!
Hi Ralph, Thank you very much for providing all these references. These links will be very helpful to chemistry students for risk assessment purposes. Excellent.
Thermal Safety of Chemical Processes: Risk Assessment and Process Design, Second, Completely Revised and Extended Edition
Author(s): Francis Stoessel
First published:13 March 2020
Print ISBN:9783527339211
Online ISBN:9783527696918
DOI:10.1002/9783527696918
Also see resources here
https://www.csb.gov/reactive-hazards/
Thanks for sharing these additional resources
This is also for your consideration. I forgot to include it along with the other link…. https://www.csb.gov/laboratory-safety/
It appears when posting Stoessel’s book, the following may have inadvertently disappeared and it is an important resource that should be listed. Thank you. https://pubs.acs.org/doi/10.1021/acs.oprd.0c00226
Process Safety in the Pharmaceutical Industry—Part I: Thermal and Reaction Hazard Evaluation Processes and Techniques
Thanks for noticing this. I have replaced the OPRD article reference, as well as the CSB link you suggested.
– Ralph